WebTuberculous meningitis patients (n = 22) showed the same allele and genotype frequency as PTB patients. No SLC11A2 polymorphisms tested were associated with TB. CONCLUSION: The 5′ (GT) n allele driving the highest rate of transcription of SLC11A1 appears to be associated with protection against TB in the majority of the populations studied. WebMay 1, 2006 · A patient suffering from microcytic anemia and hepatic iron overload was found to be compound heterozygote for polymorphisms in the iron transporter DMT1 (Nramp2, SLC11A2), including a 3-bp...
A genome-wide meta-analysis yields 46 new loci associating with ...
WebSLC11A2 expression is increased in the intestine of patients with type 2 diabetes in association with iron stores and serum hepcidin levels. Results indicate that there is a … WebThe SLC11A2 gene provides instructions for making a protein called divalent metal transporter 1 (DMT1). Four different versions (isoforms) of the DMT1 protein are ... Two new human DMT1 gene mutations in a patient with microcytic anemia, lowferritinemia, and liver iron overload. Blood. 2006 May 15;107(10):4168-70. laura wherry nyu
SLC11A1 (NRAMP1) but not SLC11A2 (NRAMP2) polymorphisms are ... - PubMed
WebObjective: To investigate whether the reported association between SLC11A1 (also NRAMP1) polymorphisms and susceptibility to tuberculosis (TB) can be confirmed in a different population, and whether polymorphisms in SLC11A2 (also NRAMP2, DCT1, DMT1) are associated with TB. WebWe conclude that the novel SLC11A2 mutation causes an abnormal splicing in intestinal cells with a consequent local reduction of SLC11A2 protein and a defect in SLC11A2 expression in erythroid cells that impairs haemoglobin production. WebApr 1, 2011 · SLC11A2 gene encodes the divalent metal transport 1 (DMT1) mediating iron transport in cerebral endosomal compartments. The objective of the study was to analyze DMT1 as a possible risk or... laura whisenhunt