WebApr 1, 2024 · mRNA level is controlled by factors that mediate both mRNA synthesis and decay, including the exonuclease Xrn1 - a major mRNA synthesis and decay factor. Here we show that nucleocytoplasmic shuttling of Xrn1 and of some of its associated mRNA decay factors plays a key role in determining both mRNA synthesis and decay. Shuttling is … WebAlthough several proteasome subunits have been shown to bind ubiquitin chains, many ubiquitylated substrates also associate with 26S proteasomes via "shuttling factors." …
The Rules and Functions of Nucleocytoplasmic Shuttling Proteins
WebIn addition to the shuttling factor Rad23B, we used a variety of recombinant Ubl-containing proteins with diverse cellular functions: the shuttling factors Rad23A and Ddi2, the ubiquitin ligase Parkin, the DUB Usp7, the phosphatase UBLCP1, and Ubl4A (part of the chaperone Bag6 complex). WebIt is noteworthy that another proteasome shuttling factor, UBQLN2, with similarities to RAD23B, also uses its multiple domains to undergo LLPS and association with stress granules in the cytoplasm 52. in a wash
Nuclear export of ribosomal subunits - ScienceDirect
WebTo investigate whether diazaborine also affects shuttling factor release, we purified late pre-60S particles by TAP using Arx1 as bait protein. As shown in Fig. 1A, drug treatment of the wild-type strain resulted in increased levels of the shuttling proteins Rlp24 and Nog1 and of the export factors Mex67 and Mtr2 in these pre-60S purifications. WebJun 8, 2001 · A role for shuttling proteins in coupling splicing to mRNA export has been recently demonstrated [46], [47]. The shuttling protein REF1-I or Aly is a member of the REF family of evolutionary conserved hnRNP-like proteins (see [48] and references therein). The yeast homologue of Aly is the mRNA export factor Yra1p. WebJun 1, 2005 · Findings demonstrate that neurotrophic factors are able to regulate nuclear/cytoplasmic shuttling of FoxO1 via the PI3K/Akt pathway in neuronal cells. FoxO1, a member of the FoxO subfamily of forkhead transcription factors, is an important target for insulin and growth factor signaling in the regulation of metabolism, cell cycle and … duties of port health officer