Webb11 apr. 2024 · Deubiquitinase-targeting chimeras for targeted protein stabilization Nature Chemical Biology February 24, 2024 Many diseases are driven by proteins that are aberrantly ubiquitinated and... Webb1 jan. 2003 · We have used gene targeting to inactivate Sox2, examining the phenotypic consequences in mutant embryos and in chimeras in which the epiblast is rescued with wild-type ES cells. We find a cell-autonomous requirement for the gene in both epiblast and extraembryonic ectoderm, the multipotent precursors of all embryonic and trophoblast …
Targeted Protein Degradation for Drug Discovery - Promega
Webb12 apr. 2024 · The chimeric proteins interact with complementary regions of the viral proteins and block their function, thereby serving as fusion inhibitors and forming the basis for antiviral treatments. WebbA genetic chimerism or chimera (/ k aɪ ˈ m ɪər ə, k ə-/ ky-MEER-ə, kə-) is a single organism composed of cells with more than one distinct genotype.In animals and human chimeras, this means an individual derived from two … az二劑保護力
protac简要介绍 - 知乎
Webb10 okt. 2024 · Proteolysis-targeting chimera (PROTAC) is an emerging revolutionary technology that promotes degradation of target proteins by proteolysis. AR-targeting PROTACs marked many milestones in the history of PROTAC development. In this review, the author discusses the development of AR-targeting PROTACs over the last two … WebbChief Technology Officer (CTO) Juni 2024–Jan. 20242 Jahre 8 Monate. Cambridge, UK. Setting up and directing Phoremost's targeted protein degradation technology. Leading internal and external target/asset discovery projects. Directing R&D and the establishment of screening pipelines, both wet-lab and computational. Webb31 mars 2024 · Zhang J, Huang Y, Liu W et al. Chaperone-mediated autophagy targeting chimeras (CMATAC) for the degradation of ERα in breast cancer. BIOCELL. 44(4), 591–595 (2024).Crossref, CAS, Google Scholar; 19. Dey SK, Jaffrey SR. RIBOTACs: small molecules target RNA for degradation. Cell Chem. Biol. 26(8), 1047–1049 (2024).Crossref, Medline, … az光刻胶折射率