WebJun 6, 2024 · Signs indicated paralytic EAE exacerbation with simultaneous loss of body weight (Fig. 1d), a characteristic feature of EAE that is correlated with disease severity [17, 18]. Pathological analysis of CNS tissue showed that the EAE group displayed inflammation (Fig. 1 e–g), demyelination (Fig. 1 h–j), and neuronal loss (Fig. 1 k–m ... WebApr 2, 2024 · Figure 1 Nox2-deficient mice show less inflammatory infiltration, demyelination at lumbar spinal cord after EAE induction on disease peak (17 dpi).(A) EAE disease score and (B) Body weight change among three genotypes (mean ± SEM) [n = 33 (W), 63 (H), 46 (K)].(C) Representative Hematoxylin and Eosin stains and (D) Fluoromyelin staining of …
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WebBody weight loss is a common feature of EAE that usually precedes paralysis, and low body weight remains during the recovery phase[12,30,31]. Body weight begins to increase during the chronic phase of the disease; thus, weight loss is an important sign during the acute stage of EAE. WebJul 8, 2024 · Weight and nerve function score. The weights of EAE mice was significantly lighter than those of the control mice, and the difference in weight gradually increased from the beginning of modelling, reached the peak in about 20 days, and then narrowed slightly (Fig. 1a). The scores of nerve functions increased gradually, reached the peak on day 18 … dicks north dartmouth ma
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