Chitosan osteoarthritis gene delivery

Author: vcel

August undefined, 2024

WebChitosan can act itself as a precursor or carrier for medical applications such as drug delivery, gene delivery, and wound healing. With the advancement in science technology, it was clearly observed that the amine groups present in chitosan are responsible for various properties such as antimicrobial activity, stability in a wide pH range ... WebJan 2, 2014 · The development of safe and efficient gene carriers is the key to the clinical success of gene therapy. The present study was designed to develop and evaluate the chitosan-graft-polyethylenimine (CP)/DNA nanoparticles as novel non-viral gene vectors for gene therapy of osteoarthritis.

Novel nano-microspheres containing chitosan, hyaluronic acid, …

WebMar 3, 2006 · All these studies point to the versatility and promise of chitosan as a gene carrier, although only limited in vivo efficacy has been demonstrated. Due to the complex … WebJan 2, 2014 · The present study was designed to develop and evaluate the chitosan-graft-polyethylenimine (CP)/DNA nanoparticles as novel non-viral gene vectors for gene … headley\u0027s funeral home

Chondroitin sulfate modified chitosan nanoparticles as an …

WebDec 1, 2024 · Chitosan, a biopolymer of natural origin, has been explored for its variety of applications in biomedical research, medical diagnostic aids and material science. It is the second most abundant natural biopolymer after cellulose, and considered as an excellent excipient because of its non-toxic, stable, biodegradable properties. WebChitosan can act itself as a precursor or carrier for medical applications such as drug delivery, gene delivery, and wound healing. With the advancement in science … WebConventional treatments for osteoarthritis (OA), including drug delivery and tissue engineering approaches, could not offer a high yield of cartilage repair due to the compact and exclusive structure of cartilage. Targeted and high-efficiency delivery of gene sequences is necessary to rebalance the lost homeostatic properties of the cartilage ... headley\u0027s cleaning

Nanoparticle–Cartilage Interaction: Pathology-Based Intra-articular ...

Direct chitosan-mediated gene delivery to the rabbit knee …

WebApr 12, 2024 · Chitosan is a naturally occurring polysaccharide that is derived from chitin, a major component of the exoskeletons of crustaceans such as shrimp, crab, and lobster. It has been gaining attention in the field of biotechnology and biomedicine due to its unique properties and potential applications. Chitosan is a linear polysaccharide that consists of … WebAug 31, 2024 · Chitosan-based carriers have been recently considered for transporting hydrophobic agents such as chemotherapeutic compounds, therapeutic peptides, and nucleic acids ( e.g. DNA and siRNA) [67], [68]. headley\\u0027s cottage bargaraWebIntroduction. Cartilage injury, a common clinical problem, can be caused by trauma, 1 osteoarthritis, 2 rheumatoid arthritis, 3 and exfoliative chondritis. 4 Articular cartilage is … headley\\u0027s furniture repair

"WebSep 24, 2024 · 2.1. Solubility. Chitosan is produced by deacetylation of chitin; in this process, some N-acetylglucosamine moieties are converted into glucosamine units.The presence of large amounts of protonated -NH 2 groups on the chitosan structure accounts for its solubility in acid aqueous media since its pKa value is approximately 6.5 [].When … " - Chitosan osteoarthritis gene delivery

Chitosan osteoarthritis gene delivery

Nanoparticle-Based Drug Delivery System—A Target …

WebJan 28, 2024 · Chitosan is considered as an ideal material for hydrogels for its biocompatibility, progressive degradability, non-toxic, biological activity, anti-inflammatory … WebJan 28, 2024 · A The optical images of the gelation progress. The mixture of N-chitosan and ADH presented in the sol state at room temperature, and it experienced sol-gel …

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WebJan 1, 2024 · The chitosan-based gene delivery system has several characteristics such as insignificant cellular toxicity, high gene delivery ability, targeting of particular cells, … WebApr 10, 2024 · Novel hyaluronic acid–chitosan nanoparticles as non-viral gene delivery vectors targeting osteoarthritis. International Journal of Pharmaceutics, 420 (2) (2011) ... Combining hyaluronic acid with chitosan enhances gene delivery. Journal of Nanomaterials (2014), 10.1155/2014/246347. 2014. Article 152. Google Scholar.

WebFeb 23, 2024 · Keywords: Osteoarthritis, Gene therapy, Chitosan, Hyaluronic acid, Chondroitin sulfate, Growth and differentiation factor-5 (GDF-5) plasmid. 1. ... HA and CHS enabled the non-viral vector itself to have some therapeutic effects on OA, making it much more suitable for delivery of gene therapy treatments for OA. WebAug 31, 2024 · Although gene delivery systems can be viral or non-viral, non-viral gene delivery materials are being specifically developed that could deliver the gene as a safer …

Webdesigned to develop and evaluate the chitosan-graft-polyethylenimine (CP)/DNA nanoparticles as novel non-viral gene vectors for gene therapy of osteoarthritis. WebThere are two main approaches for gene delivery using viral and non-viral gene transfer systems for treating articular cartilage defects in OA, or following joint trauma. The first is …

WebMar 3, 2006 · Next, chitosan–DNA nanoparticles containing IL-1Ra or IL-10 gene were injected directly into the knee joint cavities of osteoarthritis rabbits to clarify the in vivo …

WebNov 15, 2024 · (1) Background: Collagen is the main component of the connective tissue, playing an important role in the histological architecture and function of living organisms. Targeted therapy and improved imaging diagnosis can be obtained through collagen-binding nanoparticles that concentrate in the extracellular matrix. (2) Methods: We performed a … gold national geographicWebOct 16, 2024 · 2.2. CS-Based Modifications for Targeted Drug Delivery. When a drug enters the human body, various obstacles prevent it from reaching the disease site to elicit a specific therapeutic effect [].More importantly, drug often impart severe toxic side effects [].The current most effective strategy for solving the issues above mentioned is targeted … headley\\u0027s geneva nyWebJan 1, 2024 · Thermoresponsive DDS, chitosan-modified MoS 2 (molybdenum disulfide), was shown to release a small molecule drug, dexamethasone (Dex) ... is most commonly employed osteoarthritis therapeutic for gene delivery; currently there are two ongoing trials for intra-articular delivery using an AAV (NCT02790723) and an HDAV … gold nations of the world gold stamp issueWebJun 6, 2024 · Chitosan is a linear copolymer composed by glucosamine and N -acteyl glucosamine units, via β- (1, 4) linkages, namely 2-amino-2-deoxy-β-d-glucan (Fig. 2 a). Chitosan is the product of the deacetylation reaction of chitin (2-acetamido-2 … gold native american pendantsWebJan 2, 2014 · Abstract. The development of safe and efficient gene carriers is the key to the clinical success of gene therapy. The present study was designed to develop and … gold native wedding ringsWebMar 6, 2024 · Chitosan as a gene delivery vector should provide stability to vector-cargo complexes, protecting them from extracellular and intracellular degradation, delivering … gold nativity clipartWebJun 1, 2024 · Modifying chitosan with target ligands is a promising method for the targeted delivery of genes by delivery systems based on chitosan. Proteins, peptides, aptamers, carbohydrates, and small molecules are common ligands used to realize target delivery in gene vectors based on chitosan. gold nativity